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- Title
Drug discovery: Pocket of opportunity.
- Authors
Bollag, Gideon; Zhang, Chao
- Abstract
The authors comments on a research by scientist J.M. Ostrem and coworkers published in the journal in 2013 related to the development of anti cancer drug that targets mutant Ras proteins. They inform that Ostrem has reported a Ras inhibitor developed by them attacks the cysteine residue of the Ras G12C mutation by a thiol group. They also mention that the Ras inhibitors developed by Ostrem have a preference for guanosine diphosphate-bound Ras protein.
- Subjects
RAS proteins; OSTREM, J. M.; PROTEIN-protein interactions; MUTANT proteins; ENZYME inhibitors; GUANOSINE diphosphate; CANCER research
- Publication
Nature, 2013, Vol 503, Issue 7477, p475
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature12835