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- Title
Synthesis and biological activity of novel benzoazoles, benzoazines and other analogs functionalized by 2,4-dihydroxyphenyl moiety.
- Authors
Matysiak, Joanna; Skrzypek, Alicja; Głaszcz, Urszula; Matwijczuk, Arkadiusz; Senczyna, Bogdan; Wietrzyk, Joanna; Krajewska-Kułak, Elżbieta; Niewiadomy, Andrzej
- Abstract
Novel benzoazoles, benzoazines, benzothiazoles, benzothiazines and other related compounds possessing a 2,4-dihydroxyphenyl moiety were prepared. The compounds were obtained by the reaction of sulfinylbis[(2,4-dihydroxyphenyl)methanethione]s with the appropriate heterocyclic amines or hydrazines. The structures of the compounds were proved by IR, 1H NMR, and mass spectral data. Human cancer lines, Candida species and phytopathogenic fungi were used for the evaluation of biological potency of compounds. Additionally, drug-like properties were estimated in silico.
- Subjects
DIMETHYL sulfoxide; HETEROCYCLIC compounds; BENZOTHIAZOLE; AMINES; HYDRAZINES; PHYTOPATHOGENIC fungi
- Publication
Research on Chemical Intermediates, 2018, Vol 44, Issue 10, p6169
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-018-3483-0