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- Title
Use of silica gel-supported aluminium chloride as reusable catalyst for expeditious synthesis of a novel series of 11-amino-12-aryl-hexahydro-5-oxa-6,13-diaza-indeno[1,2- b]anthracene derivatives.
- Authors
Ghashang, Majid; Mansoor, Syed; Aswin, Krishnamoorthy
- Abstract
Efficient synthesis of a novel series of 11-amino-12-aryl-hexahydro-5-oxa-6,13-diaza-indeno[1,2- b]anthracene derivatives has been achieved by cyclocondensation of 2-amino-4,5-dihydro-4-arylpyrano[3,2- b]indole-3-carbonitriles and cyclohexanone in the presence of silica gel-supported aluminium chloride (SiO-AlCl) as catalyst under thermal conditions. Thorough optimization of the experimental conditions enabled significant rate enhancement and excellent yields. The starting 2-amino-4,5-dihydro-4-arylpyrano[3,2- b]indole-3-carbonitriles were obtained by one-pot triphenylphosphine-catalyzed multicomponent condensation of 3-hydroxyindole, malononitrile, and aromatic aldehydes. The structures of all the synthesized compounds were established by use of advanced spectroscopic techniques.
- Subjects
SILICA gel; ALUMINUM chloride; CATALYSTS recycling; AMINO compound synthesis; ANTHRACENE derivatives; RING formation (Chemistry)
- Publication
Research on Chemical Intermediates, 2015, Vol 41, Issue 9, p6665
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-014-1768-5