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- Title
Immunohistochemical identification of aquaporin 2 in the kidneys of wild boars (Sus scrofa).
- Authors
MICHAŁEK, Katarzyna; CZERNIAWSKA-PIĄTKOWSKA, Ewa; GRABOWSKA, Marta; LASZCZYŃSKA, Maria
- Abstract
Mammalian aquaporins (AQPs) are a family of at least 13 small, integral membrane proteins expressed in various fluid-transporting epithelial cells. Aquaporin 2 (AQP2) is mainly expressed in the kidneys, where it plays an important role in the reabsorption of water from the renal tubular fluid to concentrate urine. Studies of AQP2 expression in the kidneys have been performed in humans, monkeys, sheep, dogs, rabbits, rats, mice, and cattle. We analyzed the expression of AQP2 in the kidneys of wild boars (Sus scrofa). AQP2 was localized in the principal cells of collecting ducts in medullary rays penetrating the renal cortex and in the collecting duct of the renal medulla. he presence of AQP2 was confirmed mainly in the apical plasma membrane but also in the intracellular components and basolateral membrane of the principal cells of the collecting ducts. Due to the key role of AQP2 in the regulation of water balance in mammals and the lack of studies in the literature concerning analysis of this protein in wild boars, this work completes the present state of knowledge by providing new information on immunolocalization and immunoexpression of aquaporin 2 in Sus scrofa kidneys.
- Subjects
IMMUNOHISTOCHEMISTRY; AQUAPORINS; MAMMALIAN kidney physiology; MEMBRANE proteins; PROTEIN expression; EPITHELIAL cells; WILD boar
- Publication
Turkish Journal of Biology, 2015, Vol 39, Issue 5, p692
- ISSN
1300-0152
- Publication type
Article
- DOI
10.3906/biy-1412-68