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- Title
Progressive multifocal leukoencephalopathy in a patient with B-cell chronic lymphocytic leukemia after COVID-19 vaccination, complicated with COVID-19 and mucormycosis: a case report.
- Authors
Amirifard, Hamed; Shahbazi, Mojtaba; Farahmand, Ghasem; Ranjbar, Zahra; Kaeedi, Maryam; Heydari Havadaragh, Sanaz
- Abstract
Background: Progressive multifocal leukoencephalopathy (PML) is a rare and fatal opportunistic viral demyelinating infectious disease of the central nervous system (CNS). There are various clinical presenting symptoms for the disease. Case presentation: This paper presents a clinical case of PML in a patient with B-Chronic lymphocytic leukemia (B-CLL), previously treated with Chlorambucil, later complicated later with COVID-19 and mucormycosis. Conclusion: PML can develop in the setting of cellular immune dysfunction. Late diagnosis of this disease based on nonspecific symptoms is common, therefore when we face a neurological complication in a CLL or immunocompromised patient, we should consider PML infection. A remarkable feature of this case is the possible triggering effect of COVID-19 vaccination for emergence of PML as the disease can be asymptomatic or sub-clinical before diagnosis.
- Subjects
PROGRESSIVE multifocal leukoencephalopathy; JOHN Cunningham virus; CHRONIC lymphocytic leukemia; COVID-19 vaccines; MUCORMYCOSIS; COVID-19 pandemic; SYMPTOMS
- Publication
BMC Neurology, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2377
- Publication type
Case Study
- DOI
10.1186/s12883-024-03650-y