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- Title
Familiality and heritability of binge eating disorder: Results of a case-control family study and a twin study.
- Authors
Javaras, Kristin N.; Laird, Nan M.; Reichborn-Kjennerud, Ted; Bulik, Cynthia M.; Pope Jr., Harrison G.; Hudson, James I.
- Abstract
Objective: To estimate the familiality and heritability of binge eating disorder (BED). Method: We used a new ACE structural equation model to estimate heritability from a case-control family study of BED conducted in the Boston area. The sample consisted of 150 overweight/obese probands with lifetime BED by DSM-IV criteria, 150 overweight/obese probands without lifetime BED, and 888 of their first-degree relatives. We compared our findings with those from a study of binge eating (in the absence of compensatory behaviors) among 7,831 Norwegian twins. Results: The prevalence of BED differed by sex and by age. In the case-control family study, BED was found to aggregate in families, and heritability was estimated as 57% (CI: 30–77%). Including shared environment did not substantially improve the model's fit, nor did allowing sex-specific heritability. Findings from the twin study were similar. Conclusion: BED appears to aggregate in families and have a significant genetic component. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord, 2008
- Subjects
COMPULSIVE eating; EATING disorders; OBESITY; NUTRITION disorders; BODY weight; METABOLIC disorders
- Publication
International Journal of Eating Disorders, 2008, Vol 41, Issue 2, p174
- ISSN
0276-3478
- Publication type
Article
- DOI
10.1002/eat.20484