We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
From Mouth to Muscle: Exploring the Potential Relationship between the Oral Microbiome and Cancer-Related Cachexia.
- Authors
Raman, Shreya R.; Liu, Christopher; Herremans, Kelly M.; Riner, Andrea N.; Vudatha, Vignesh; Freudenberger, Devon C.; McKinley, Kelley L.; Triplett, Eric W.; Trevino, Jose G.
- Abstract
Cancer cachexia is a multifactorial wasting syndrome associated with skeletal muscle and adipose tissue loss, as well as decreased appetite. It affects approximately half of all cancer patients and leads to a decrease in treatment efficacy, quality of life, and survival. The human microbiota has been implicated in the onset and propagation of cancer cachexia. Dysbiosis, or the imbalance of the microbial communities, may lead to chronic systemic inflammation and contribute to the clinical phenotype of cachexia. Though the relationship between the gut microbiome, inflammation, and cachexia has been previously studied, the oral microbiome remains largely unexplored. As the initial point of digestion, the oral microbiome plays an important role in regulating systemic health. Oral dysbiosis leads to the upregulation of pro-inflammatory cytokines and an imbalance in natural flora, which in turn may contribute to muscle wasting associated with cachexia. Reinstating this equilibrium with the use of prebiotics and probiotics has the potential to improve the quality of life for patients suffering from cancer-related cachexia.
- Subjects
CACHEXIA; WASTING syndrome; GUT microbiome; HUMAN microbiota; SKELETAL muscle; ADIPOSE tissues
- Publication
Microorganisms, 2022, Vol 10, Issue 11, p2291
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms10112291