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- Title
Synthesis and Nucleophilic Properties of 1-(2-Methoxyethyl)- and 1-(2-Phenoxyethyl)-3,3-dialkyl-3,4-dihydroisoquinolines.
- Authors
Mikhailovskii, A. G.; Yusov, A. S.; Pershina, N. N.
- Abstract
The Ritter reaction of dialkyl benzyl carbinols with 3-methoxy- and 3-phenoxypropanenitriles afforded the corresponding 1-(2-methoxyethyl)- and 1-(2-phenoxyethyl)-3,3-dialkyl-3,4-dihydroisoquinolines. Likewise, benzo[f]isoquinoline derivatives were synthesized from 2-methyl-3-(naphthalen-1-yl)-propan-2-ol. The obtained compounds were shown to have the imine structure, but they exhibited enamine properties. In particular, their reactions with oxalyl chloride resulted in pyrrole annulation.
- Subjects
OXALYL chloride; PYRROLES; ANNULATION; ENAMINES; ISOQUINOLINE
- Publication
Russian Journal of Organic Chemistry, 2024, Vol 60, Issue 4, p606
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428024040067