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- Title
The Study of cis-trans Equilibrium and Complexation with DNA of meso-Substituted Carbocyanine Dyes.
- Authors
Pronkin, P. G.; Tatikolov, A. S.; Anikovskii, M. Yu.; Kuz'min, V. A.
- Abstract
The effect of DNA was studied on cis-trans equilibrium and spectral and fluorescent properties of a number of meso-substituted carbocyanine dyes: 3,3′-diethyl-9-thiomethylthiacarbocyanine iodide (K1), 3,3′-diethyl-9-methoxythiacarbocyanine iodide (K2), 3,3′-9-triethylthiacarbocyanine iodide (K3), 3,3′-dimethyl-9-ethyloxacarbocyanine iodide (K4), 3,3′-9-triethyl-5,5′-dimethyloxacarbocyanine iodide (K5), and 3,3′,9-triethyl-6,6′-dimethoxyoxacarbocyanine iodide (K6). Equilibrium between the cis and trans isomeric forms was detected for the thiacarbocyanine dyes in a number of organic solvents, with a shift of the equilibrium toward the cis-isomer caused by an increase in the solvent polarity. The oxacarbocyanines are present only in the form of trans-isomers in both polar and nonpolar solvents. Interaction of the dyes with DNA leads to the formation of stable noncovalent complexes. The complexation of the thiacarbocyanine dyes results in a shift of the isomeric equilibrium and occurs predominantly via the cis-form of the dye. The oxacarbocyanine dyes produce complexes with DNA in the initial trans-form.
- Subjects
CIS-trans-isomerases; ISOMERASES; ENZYMES; DYES &; dyeing; DNA; DEOXYRIBOSE; NUCLEIC acids
- Publication
High Energy Chemistry, 2005, Vol 39, Issue 4, p237
- ISSN
0018-1439
- Publication type
Article
- DOI
10.1007/s10733-005-0048-8