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- Title
DCI after Aneurysmal Subarachnoid Hemorrhage Is Related to the Expression of MFG-E8.
- Authors
Chen, Xianjun; Jiang, Yong'an; Liu, Jiayu; Wang, Changfeng; Wan, Dengfeng; Liang, Ai'jun; Leng, Jingxing; Yang, Yu; Xiang, Hui; Liu, Ru'en
- Abstract
Objective. To explore the predictive value of milk fat globule epidermal growth factor 8 (MFG-E8) in the occurrence of delayed cerebral ischemia (DCI) after an aneurysmal subarachnoid hemorrhage (aSAH). Methods. We recruited 32 patients with aSAH as the case group and 24 patients with unruptured aneurysms as the control group. Serum MFG-E8 levels were measured by western blot and enzyme-linked immunosorbent assay. We analyzed the relationship between MFG-E8 levels and the risk of DCI. Results. The levels of serum MFG-E8 in the case group (mean = 11160.9 pg/mL) were significantly higher than those in the control group (mean = 3081.0 pg/mL, p < 0.001). MFG-E8 levels highly correlated with the World Federation of Neurosurgical Societies (WFNS) and modified Fisher scores (r = − 0.691 and − 0.767 , respectively, p < 0.001). In addition, MFG-E8 levels in patients with DCI (5882.7 ± 3162.4 pg/mL) were notably higher than those in patients without DCI (15818.2 ± 3771.6 pg/mL, p < 0.001). A receiver operating characteristic curve showed that the occurrence of DCI could effectively be predicted by MFG-E8 (area under the curve = 0.976 , 95 % CI = 0.850 – 1.000). Kaplan–Meier survival analysis showed a remarkable decrease in the incidence of DCI in case group individuals with high levels of MFG-E8 (≥11160.9 pg/mL, p < 0.001). Conclusion. MFG-E8 may be a useful predictive marker for DCI after an aSAH and could be a promising surrogate end point.
- Subjects
PREDICTIVE tests; CONFIDENCE intervals; SUBARACHNOID hemorrhage; COMPARATIVE studies; MILK proteins; DESCRIPTIVE statistics; KAPLAN-Meier estimator; SURVIVAL analysis (Biometry); THERAPEUTIC complications; RECEIVER operating characteristic curves; INTRACRANIAL aneurysms; CEREBRAL ischemia; ANTIGENS
- Publication
BioMed Research International, 2021, Vol 2021, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2021/6568477