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- Title
SYSTEMIC TREATMENT OF SEVERE ATOPIC DERMATITIS IN ADULTS: RESTROSPECTIVE, COMPARATIVE ANALYSIS OF 81 PATIENTS.
- Authors
KOSTIĆ, Kristina; ŠOFRANAC, Dušan; KANDOLF SEKULOVIĆ, Lidija; ZEČEVIĆ, Radoš
- Abstract
OBJECTIVE: To analyse and compare effi cacy, safety and duration of therapy with cyclosporine, phototherapy and systemic corticosteroids in patients with severe forms of AD MATERIALS & METHODS: Retrospective analysis of patients with severe forms of atopic dermatitis treated at our hospital from 2003-2014 was done. Hospital database was used for the retrieval of data. The severity of AD was evaluated based on SCORAD and EASI index. Duration of therapy, adverse events, treatment effi cacy and reasons for stopping of treatment were recorded on follow-up examination of the patients. RESULTS: There were 81 patients with AD, 34 females and 47 man. Nineteen patients (23.4%) were treated with cyclosporine, 20/81 (24.6%) patients with phototherapy and 42/81 (51.8%) with systemic corticosteroids For patients treated with nbUVB phototherapy 2-3 times weekly schedule was commenced, the average cumulative dose was 34393 mJ/cm2, and average treatment number to disease clearance and stopping the treatment was 28. Duration of treatment with systemic corticosteroids until remission of disease was from 4 to 33weeks and treatment period in patients with cyclosporine was from 8 to 48 weeks. In three patients treated with cyclosporine (15,98%) and in 20 patients (47,6%) treated with systemic corticosteroids we noted arterial hypertension. During phototherapy in patients with AD we didn't fi nd any adverse effects. CONCLUSION: Based on this study, nbUVB and cyclosporine can be regarded as safe and effective treatment modalities and they can be recommended as the fi rst line therapy in severe forms of atopic dermatitis refractory to topical therapy.
- Publication
Balkan Military Medical Review, 2014, Vol 17, p48
- ISSN
1107-6275
- Publication type
Article