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- Title
Network Pharmacology Reveals Curcuma aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia.
- Authors
Sintos, Aaron Marbyn L.; Cabrera, Heherson S.
- Abstract
Simple Summary: Androgenetic alopecia (AGA) represents the most common form of hair loss experienced by both men and women. Curcuma aeruginosa Roxb., a plant known for its medicinal properties, has shown promise in reversing this hair loss disorder for its hair growth effects and anti-androgenic effects. Despite its promising potential, the mechanism of action by which it acts remains unknown. As such, this study unveiled how this plant works against hair loss by identifying its bioactive compounds, the gene its targets, and the potential mechanism involved in the therapy of AGA using network pharmacology and molecular docking. The findings revealed insights into how C. aeruginosa can potentially prevent AGA, highlighting its potential for developing new, safe therapies for AGA, benefiting those affected by this condition. Androgenetic alopecia (AGA) is the most prevalent hair loss disorder worldwide, driven by excessive sensitivity or response to androgen. Herbal extracts, such as Curcuma aeruginosa Roxb., have shown promise in AGA treatment due to their anti-androgenic activities and hair growth effects. However, the precise mechanism of action remains unclear. Hence, this study aims to elucidate the active compounds, putative targets, and underlying mechanisms of C. aeruginosa for the therapy of AGA using network pharmacology and molecular docking. This study identified 66 bioactive compounds from C. aeruginosa, targeting 59 proteins associated with AGA. Eight hub genes were identified from the protein–protein interaction network, namely, CASP3, AKT1, AR, IL6, PPARG, STAT3, HIF1A, and MAPK3. Topological analysis of components–targets network revealed trans-verbenol, myrtenal, carvone, alpha-atlantone, and isoaromandendrene epoxide as the core components with potential significance in AGA treatment. The molecular docking verified the binding affinity between the hub genes and core compounds. Moreover, the enrichment analyses showed that C. aeruginosa is involved in hormone response and participates in HIF-1 and MAPK pathways to treat AGA. Overall, this study contributes to understanding the potential anti-AGA mechanism of C. aeruginosa by highlighting its multi-component interactions with several targets involved in AGA pathogenesis.
- Subjects
ELECTRIC network topology; MOLECULAR docking; HAIR growth; MOLECULAR pharmacology; BALDNESS
- Publication
Biology (2079-7737), 2024, Vol 13, Issue 7, p497
- ISSN
2079-7737
- Publication type
Article
- DOI
10.3390/biology13070497