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- Title
Evaluation of the hydroalcoholic extract of Clarisia racemosa as an antiparasitic agent: an in vitro approach.
- Authors
da Cruz Filho, Iranildo José; Duarte, Denise Maria Figueiredo Araújo; Marques, Diego Santa Clara; da Rocha, João Victor Ritinto; Diniz, Emily Gabriele Marques; Brayner, Fábio André; Alves, Luiz Carlos; de Azevedo Albuquerque, Mônica Camelo Pessoa; de Lima Aires, André; Nogueira, Fátima; de Lima, Maria do Carmo Alves
- Abstract
Clarisia racemosa Ruiz & Pav is a neotropical species found in humid forests from southern Mexico to southern Brazil. There are few studies related to the ethnopharmacological use of C. racemosa. Our objective was to evaluate the hydroalcoholic extract of C. racemosa as a potential antiparasitic agent. For this, we performed in vitro assays against strains of Leishmania amazonensis, Trypanosoma cruzi, Plasmodium falciparum, and Schistosoma mansoni. At the same time, immunomodulatory activity tests were carried out. The results demonstrated that the extract was able to stimulate and activate immune cells. In preliminary antiparasitic tests, structural modifications were observed in the promastigote form of L. amazonensis and in adult worms of S. mansoni. The extract was able to inhibit the growth of trypomastigote form of T. cruzi and finally showed low antiparasitic activity against strains of P. falciparum. It is pioneering work and these results demonstrate that C. racemosa extract is a promising alternative and contributes to the arsenal of possible forms of treatment to combat parasites.
- Subjects
AMAZON River Region; MEXICO; BRAZIL; ANTIPARASITIC agents; SCHISTOSOMA mansoni; TRYPANOSOMA cruzi; PLASMODIUM falciparum; PLASMODIUM; PROMASTIGOTE
- Publication
3 Biotech, 2023, Vol 13, p1
- ISSN
2190-572X
- Publication type
Article
- DOI
10.1007/s13205-023-03799-2