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- Title
Four newly isolated fuselloviruses from extreme geothermal environments reveal unusual morphologies and a possible interviral recombination mechanism.
- Authors
Redder, Peter; Peng, Xu; Brügger, Kim; Shah, Shiraz A.; Roesch, Ferdinand; Greve, Bo; She, Qunxin; Schleper, Christa; Forterre, Patrick; Garrett, Roger A.; Prangishvili, David
- Abstract
Spindle-shaped virus-like particles are abundant in extreme geothermal environments, from which five spindle-shaped viral species have been isolated to date. They infect members of the hyperthermophilic archaeal genus Sulfolobus, and constitute the Fuselloviridae, a family of double-stranded DNA viruses. Here we present four new members of this family, all from terrestrial acidic hot springs. Two of the new viruses exhibit a novel morphotype for their proposed attachment structures, and specific features of their genome sequences strongly suggest the identity of the host-attachment protein. All fuselloviral genomes are highly conserved at the nucleotide level, although the regions of conservation differ between virus-pairs, consistent with a high frequency of homologous recombination having occurred between them. We propose a fuselloviral specific mechanism for interviral recombination, and show that the spacers of the Sulfolobus CRISPR antiviral system are not biased to the highly similar regions of the fusellovirus genomes.
- Subjects
DNA viruses; VIRUS morphology; GENOMES; VIRAL genetics; GENETIC recombination
- Publication
Environmental Microbiology, 2009, Vol 11, Issue 11, p2849
- ISSN
1462-2912
- Publication type
Article
- DOI
10.1111/j.1462-2920.2009.02009.x