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- Title
How do you initiate oestrogen therapy in a girl who has not undergone puberty?
- Authors
Hindmarsh, Peter C.
- Abstract
The physiology of puberty needs to be taken into consideration in the induction of puberty. Puberty is a relatively slow process and replacement therapy should mimic this. Long-term maintenance requires careful monitoring and long-term assessment of risk-benefit. This has not been appreciably defined in the adolescent population. Options for fertility need careful consideration and may depend on the adequacy of pubertal induction in terms of uterine development. A number of regimens are available for pubertal induction but the lack of comparisons makes it difficult to advocate for a particular regimen. There remain a number of areas of uncertainty, and future studies need to consider these issues and whether there are cardiovascular risk factor advantages to certain preparations. The long-term risks of breast and gynaecological malignancy remain uncertain. Long-term cohort studies are required to address these issues.
- Subjects
PUBERTY; PHYSIOLOGY; SEX (Biology); SEX hormones; STEROID hormones
- Publication
Clinical Endocrinology, 2009, Vol 71, Issue 1, p7
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/j.1365-2265.2009.03553.x