We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparisons of survival and complications between minimally invasive and open staging surgery in non-endometrioid endometrial cancer.
- Authors
Lee, Maria; Dong Won Hwang; Se Ik Kim; Hee Seung Kim; Hyun Hoon Chung; Jae-Weon Kim; Noh Hyun Park
- Abstract
Objective: To compare survival outcomes and complications between minimally invasive surgery (MIS) and open surgery groups and evaluate risk factors related to survival in nonendometrioid endometrial cancer (EC). Methods: We identified patients with non-endometrioid EC who underwent primary staging surgery by laparoscopic, robotic or open abdominal surgery from 2004 to 2017. Clinicopathologic characteristics, survival outcomes, and surgical complications were compared between the MIS and open surgery groups. Prognostic factors associated with progression-free survival (PFS) and overall survival (OS) were also investigated. Results: In total, 91 patients were included: 41 and 50 received MIS and open surgery, respectively. The MIS and open surgery groups showed similar PFS (5-year PFS rate: 58.7% vs. 58.5%, p=0.925) and OS (5-year OS rate: 73.6% vs. 80.3%, p=0.834). Intraoperative (7.2% vs. 6.0%, p=0.111) and postoperative surgical complications (14.6% vs. 26.0%, p=0.165) were similar between the 2 surgical groups. However, blood loss was lower (mean, 305.1 vs. 561.2 mL, p<0.001) and hospital stay was shorter (mean, 8.2 vs. 15.4 days, p<0.001) in the MIS group. In multivariate analysis, lymphovascular space invasion (LVSI) was identified as a poor prognostic factor for PFS (adjusted hazard ratio [HR]=3.054; 95% confidence interval [CI]=1.521-6.132; p=0.002) and OS (adjusted HR=3.918; 95% CI=1.455-10.551; p=0.007), whereas age ≥60 years was a poor prognostic factor for only OS (adjusted HR=5.0953; 95% CI=1.660-15.378; p=0.004). Conclusion: No difference in surgical outcomes was founded between MIS and open surgery group in non-endometrioid EC. And LVSI is a valid factor for survival in non-endometrioid EC.
- Subjects
ENDOMETRIAL surgery; ENDOMETRIAL cancer; MINIMALLY invasive procedures; SURVIVAL rate; OVERALL survival; PROGRESSION-free survival
- Publication
Journal of Gynecologic Oncology, 2024, Vol 35, p32
- ISSN
2005-0380
- Publication type
Article
- DOI
10.3802/jgo.2024.35.S2.P22