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- Title
Human Pluripotent Stem Cells to Model Islet Defects in Diabetes.
- Authors
Balboa, Diego; Iworima, Diepiriye G.; Kieffer, Timothy J.
- Abstract
Diabetes mellitus is characterized by elevated levels of blood glucose and is ultimately caused by insufficient insulin production from pancreatic beta cells. Different research models have been utilized to unravel the molecular mechanisms leading to the onset of diabetes. The generation of pancreatic endocrine cells from human pluripotent stem cells constitutes an approach to study genetic defects leading to impaired beta cell development and function. Here, we review the recent progress in generating and characterizing functional stem cell-derived beta cells. We summarize the diabetes disease modeling possibilities that stem cells offer and the challenges that lie ahead to further improve these models.
- Subjects
HUMAN stem cells; PLURIPOTENT stem cells; ISLANDS of Langerhans; PANCREATIC beta cells; CELL physiology
- Publication
Frontiers in Endocrinology, 2021, Vol 11, pN.PAG
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2021.642152