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- Title
Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia.
- Authors
Chunbin Zou; Jin Li; Sheng Xiong; Yan Chen; Qin Wu; Xiuying Li; Weathington, Nathaniel M.; SeungHye Han; Snavely, Courtney; Chen, Bill B.; Mallampalli, Rama K.
- Abstract
The article discusses a study focusing on the mediation of epithelial cell death in a mouse model of pneumonia by mortality factor 4 like 1 (Morf4l1) protein. Topics discussed include the involvement of Morf4l1 in chromatin remodeling, the effect of exposure to pseudomonas aeruginosa or lipopolysaccharide on Morf4l1 in humans, and the lung epithelial cell death due to overexpression of Morf4l1 in mice.
- Subjects
EPITHELIAL cells; CELL death; PROTEIN expression; ANIMAL disease models; PSEUDOMONAS aeruginosa infections; GENETIC overexpression
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 311, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aac7793