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- Title
Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.
- Authors
Hong Cai; Scott, Edwina; Kholghi, Abeer; Andreadi, Catherine; Rufini, Alessandro; Karmokar, Ankur; Britton, Robert G.; Horner-Glister, Emma; Greaves, Peter; Jawad, Dhafer; James, Mark; Howells, Lynne; Ognibene, Ted; Malfatti, Michael; Goldring, Christopher; Kitteringham, Neil; Walsh, Joanne; Viskaduraki, Maria; West, Kevin; Miller, Andrew
- Abstract
The article looks at a study regarding cancer chemoprevention and the evidence of nonlinear dose response for the protective effects of resveratrol in humans and mice. It mentions efficacy correlated with activation of adenosine monophosphate–activated protein kinase (AMPK) and increased expression of the senescence marker. It also mentions expression of the cytoprotective NAD(P)H dehydrogenase, quinone 1 (NQO1) enzyme increased in tissues from cancer patients.
- Subjects
CHEMOPREVENTION; PREVENTIVE medicine; RESVERATROL; ADENOSINE monophosphate; GENE expression; NAD (Coenzyme); QUINONE
- Publication
Science Translational Medicine, 2015, Vol 7, Issue 298, p1
- ISSN
1946-6234
- Publication type
Article
- DOI
10.1126/scitranslmed.aaa7619