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- Title
Effects of Short-term Temperature Change in the Innocuous Range on Histaminergic and Non-histaminergic Acute Itch.
- Authors
LEWIS, Zoe; GEORGE, David N.; COWDELL, Fiona; HOLLE, Henning
- Abstract
While temperatures in the noxious range are wellknown to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating shortterm temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. Results indicate that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch, in line with previous findings. Skin warming increased cowhage-induced itch intensity. Potential mechanisms of this interaction between thermosensation and pruritoception could involve cold-sensitive channels such as TRPM8, TREK-1 or TRPC5 in the case of histamine. The rapid modulation of cowhage induced itch - but not histamine-induced itch - by transient skin warming could be related to the lower temperature threshold of pruriceptive polymodal C-fibres (cowhage) as compared to the higher temperature threshold of the mechanoinsensitive C-fibres conveying histaminergic itch.
- Subjects
ITCHING; TEMPERATURE effect; SKIN temperature; INDIVIDUAL differences; LOW temperatures; HIGH temperatures
- Publication
Acta Dermato-Venereologica, 2019, Vol 99, Issue 2, p188
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-3077