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- Title
Alanin Aminotransferaz Düzeyi Normal Kronik Hepatit C İnfeksiyonlu Hastaların Karaciğer Histolojileri.
- Authors
Aygen, Bilgehan; Deniz, Kemal; Akhan, Sıla; Kemal Çelen, Mustafa; Yıldız, Orhan; Ayaz, Celal; Ali Doğan, Suat; Erten, Siraç; Sargın-Altunok, Elif; Gökahmetoğlu, Selma; Büyükbayram, Hüseyin; Ercan Patıroğlu, Tahir
- Abstract
Objective: In this study, our objective is to evaluate histological changes in livers of hepatitis C virus (HCV)-infected patients with normal alanine aminotransferase (ALT) levels. Methods: 72 patients over 16 years old, with chronic hepatitis C (CHC) and normal ALT levels were evaluated in this multicenter retrospective study. Persistently normal ALT level was defined as 2 or 3 normal ALT levels at intervals of at least 1 month during 6 months. Demographic data, year of diagnosis, at least 2 ALT values within 6 months, hepatitis markers, results of HCV RNA and the liver biopsy were all evaluated. Serological markers have been tested with different kits. HCV RNA has been studied by RT-PCR with dynamic range and sensitivity of different kits. All biopsies were evaluated again by the same pathologist. Results: The mean age was 44 ± 13 years and 61.1% were female. HCV RNA levels were between 1.53x102-1.13x108 IU/ml. The mean ALT levels were 30.3± 9.6 IU/lt. The mean grade of necroinflammation was 4.67 ±1.96 and mean staging of fibrosis was 1.03± 1.13. The ratios of minimal, mild and moderate activity in the liver biopsies were 48.6%, 45.3% and, 2.8%, respectively. Rate of portal-periportal fibrosis, bridging fibrosis and incomplete cirrhosis were 51.4%, 6.9%, and 1.4%, respectively. Conclusions: ALT level is a poor indicator of liver disease activity in patients with CHC. Patients with indication for treatment should be evaluated for liver biopsy.
- Subjects
RNA analysis; BIOMARKERS; BIOPSY; HEPATITIS C; LIVER; LIVER diseases; MEDICAL cooperation; POLYMERASE chain reaction; RESEARCH; ALANINE aminotransferase; RETROSPECTIVE studies; REVERSE transcriptase polymerase chain reaction; DESCRIPTIVE statistics
- Publication
Klimik Journal / Klimik Dergisi, 2012, Vol 25, Issue 1, p19
- ISSN
1301-143X
- Publication type
Article
- DOI
10.5152/kd.2012.06