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- Title
Convenient Synthesis of Functionalized Unsymmetrical Vinyl Disulfides and Their Inverse Electron-Demand Hetero-Diels-Alder Reaction †.
- Authors
Jędrzejewski, Bartosz; Musiejuk, Mateusz; Doroszuk, Justyna; Witt, Dariusz; Pawelec, Barbara; Gregory, Duncan
- Abstract
The simple, convenient, and efficient methods for the preparation of unsymmetrical vinyl disulfides with additional functional groups under mild conditions with moderate to high yields were designed. The developed methods include the reaction of S-vinyl phosphorodithioate with thiotosylates or S-vinyl thiotosylate with thiols. The designed methods allow for the synthesis of unsymmetrical vinyl disulfides with additional functionalities such as hydroxy, carboxy, protected amino, or ester groups. Vinyl disulfides reacted with the generated transient o-iminothioquinones in an inverse electron-demand [4+2] cycloaddition to produce benzo[b][1,4]thiazine derivatives.
- Subjects
DISULFIDES; FUNCTIONAL groups; RING formation (Chemistry); HYDROXY esters; DIELS-Alder reaction; THIOLS
- Publication
Materials (1996-1944), 2021, Vol 14, Issue 6, p1342
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma14061342