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- Title
Rheumatoid arthritis: An overview of epigenetics and pathogenesis.
- Authors
George, Remi Liza; Jyothi, Y.; Khan, Saira
- Abstract
Rheumatoid arthritis (RA) is a progressive autoimmune disease specified by significant morbidity, loss of functional capacity, and whose pathogenic mechanisms remain to be elucidated. The greater risk of RA is for women when compared to men. The evidence obtained from analyses of genetic tissue and clinical studies suggest an immune-mediated etiology correlated with dysregulation of stromal tissue, which spreads chronic inflammation and joint destruction together. RA includes a complicated genotype interplay and environmental triggers. The presence of circulating autoantibodies, various chemokines, and modified metabolism occurs in the body helps in the characterization of RA. From the earlier studies, it is known that the suppression of pro-inflammatory cytokine-mediated Janus kinase/signal transducer and activator of transcription, mitogen-activated protein kinase, or Syk activation may be adequate but not in terms of clinical aspect. Nevertheless, a large proportion of RA patients do not show much response to the current therapies. New interventions and medications are urgently required. This review addresses the recent awareness of the epigenetics, pathological pathways in the progression of RA, and also a short overview of the current therapies of RA.
- Subjects
RHEUMATOID arthritis; MITOGEN-activated protein kinases; AUTOIMMUNE diseases; STAT proteins; AUTOANTIBODIES
- Publication
Drug Invention Today, 2020, Vol 14, Issue 2, p248
- ISSN
0975-7619
- Publication type
Article