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- Title
The effectiveness of ethanol extract of purple sweet potato var. Ayamurasaki as a natural antihypertensive mitigator in deoxycorticosterone acetate-salt hypertensive rats.
- Authors
Rahmawati, Irma Sarita; Soetjipto, Soetjipto; Adi, Annis Catur; Aulanni'am, Aulanni'am
- Abstract
Backgorund: There is an increasing amount of evidence that oxidative stress related to hypertension can damage the function of diverse structures such as the aorta and kidney. It is a well-established fact that chlorogenic acid and anthocyanin found in purple sweet potato generate bioactive compound with antihypertensive and antioxidative activities. Purpose: The present study sought to investigate blood pressure-lowering effect and antioxidative activity of ethanol extract of purple sweet potato (EP) in deoxycorticosterone acetate/sodium chloride (DOCA-salt)-induced hypertensive rats (Rattus norvegicus). Methods: Rats were orally administrated 95% ethanol extract of purple sweet potato (var. Ayamurasaki) in a daily dose of 100 and 200 mg/kg body weight for 4 weeks. Systole blood pressure (SBP) and renal and aorta total malondialdehyde (MDA) were assessed. Results: Mean SBP was lowered in the hypertensive rats following EP therapy from their values at the time of administration. Renal and aorta injury was observed in the DOCA-salt hypertensive rats compared to normotensive group rats; renal and aorta MDA significantly increased (P < 0.05). In contrast, treatment of DOCA-salt in hypertensive rats with a different dose of EP significantly reduced the total renal and aorta MDA. Conclusion: This is the first report that demonstrates the lowering of blood pressure and antioxidative effects of an ethanol extract of purple sweet potato, containing chlorogenic acid, in a DOCA-salt model of hypertension.
- Subjects
SWEET potatoes; CHLOROGENIC acid; RATTUS norvegicus; BLOOD pressure; RATS; ETHANOL
- Publication
Drug Invention Today, 2019, Vol 11, Issue 12, p3179
- ISSN
0975-7619
- Publication type
Article