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- Title
Inhibition effect of silver-calcium nanocomposite on alanine transaminase enzyme activity in human serum of Iraqi patients with chronic liver disease.
- Authors
Rheima, Ahmed Mahdi; Mohammed, Mahdi A.; Jaber, Shaimaa Hamed; Hasan, Mohammed Husham
- Abstract
Silver-calcium (Ag-Ca) nanocomposite was synthesized by the chemical reduction method. The nanocomposite was investigated by X-ray diffraction and scanning electron microscope. It was shown that the particles in the nanocomposite were about 16.8 nm in average crystal size. The effect of Ag-Ca nanocomposite was studied on the activity of alanine transaminase (ALT) in the serum patients of chronic liver disease. The results have shown that there was a highly significant increase in the serum levels of ALT activity in patients of chronic liver disease with and without nanocomposite compared to the control group (P < 0.001). A highly significant decrease in the serum levels of ALT activity in patients of chronic liver disease with nanocomposite compared to serum patients without nanocomposite. The result was related to the observation that Ag-Ca nanocomposite had an inhibition effect on serum ALT activity because the Ag-Ca nanocomposite strongly interacts with carboxylic groups of vital enzyme and inactivate them.
- Publication
Drug Invention Today, 2019, Vol 12, Issue 11, p2818
- ISSN
0975-7619
- Publication type
Article