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- Title
Effect of chebulagic acid on apoptotic regulators in prostate cancer cell line - PC-3.
- Authors
Ponnulakshmi, R.; Shyamaladevi, B.; Selvaraj, J.; Valli, G.; Purushothaman, V.; Alsawalha, Murad; Mohan, Surapaneni Krishna
- Abstract
Background: Prostate cancer (PCa) is the second most typical cancer and also the sixth leading reason behind cancer death among men worldwide with associate degree calculable recorded amount of 1.1 million cases and 307,000 deaths in 2012. Chebulagic acid (CA), a benzopyran tannin, is one of the major bioactive compounds present in the fruits of Terminalia chebula. Aim: The present study was aimed at assessing the effects of CA on proapoptotic (Bax) and antiapoptotic protein molecules such as B-cell lymphoma-2 (Bcl-2) and Bcl-extra large (Bcl-xl) in PC-3 cell line. Materials and Methods: Antiproliferative potential of CA was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. PC-3 cells were treated with different concentration of CA (1, 5, 10, 25, 50, and 100 μM). Pro- and anti-apoptotic proteins were done by western blotting methods. PC-3 cells were treated with the treatment of CA resulted in a dose-dependent inhibition of the growth of PC-3 cells. This was associated with increased levels of proapoptotic protein (Bax) and the reduced levels of the antiapoptotic proteins Bcl-2 and Bcl-xL. Conclusion: The present findings clearly suggest that CA induces apoptosis by the regulating intrinsic pathways which could be very useful for the treatment of PCa.
- Subjects
APOPTOSIS; CANCER cells; PROSTATE cancer; B cells; BIOACTIVE compounds
- Publication
Drug Invention Today, 2019, Vol 12, Issue 2, p281
- ISSN
0975-7619
- Publication type
Article