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- Title
A possible role of vitamin D in the genesis of parenteral-nutrition-induced metabolic bone disease.
- Authors
Shike, Moshe; Sturtridge, William C.; Tam, Cherk S.; Harrison, Joan E.; Jones, Glenville; Murray, Timothy M.; Husdan, H.; Whitwell, Jocelyn; Wilson, Douglas R.; Jeejeebhoy, Khursheed N.; Shike, M; Sturtridge, W C; Tam, C S; Harrison, J E; Jones, G; Murray, T M; Whitwell, J; Wilson, D R; Jeejeebhoy, K N
- Abstract
Patients receiving long term parenteral nutrition may develop metabolic bone disease. In all 11 patients studied, histologic studies of bone showed excessive unmineralized bone tissue despite normal plasma 25-hydroxyvitamin D levels. Three patients also had bone pain and fractures and severe urinary loss of calcium and phosphate. Withdrawal of vitamin D from parenteral nutrition solutions was associated with improved histologic findings of bone in all patients, shown by a decrease in osteoid tissue and an increase in tetracycline uptake. In the three patients with symptoms, bone pain subsided, fractures healed, and urinary loss of calcium and phosphate decreased. Thus, vitamin D may be a factor in the genesis of parenteral nutrition-induced metabolic bone disease.
- Subjects
METABOLIC bone disorders; VITAMIN D
- Publication
Annals of Internal Medicine, 1981, Vol 95, Issue 5, p560
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-95-5-560