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- Title
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.
- Authors
Luna, Augustin; Aladjem, Mirit I.; Kohn, Kurt W.
- Abstract
An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulators of DNA damage response and circadian rhythms. We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins. Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those interactions in DNA repair and ultimately, cell fate decisions.
- Subjects
DNA damage; DNA metabolism; NICOTINAMIDE adenine dinucleotide phosphate; MOLECULAR interactions; PROTEIN research; GENETIC toxicology; DNA repair
- Publication
Genome Integrity, 2013, Vol 4, Issue 1, p2
- ISSN
2041-9414
- Publication type
Article
- DOI
10.1186/2041-9414-4-6