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- Title
Patterns of Th1/Th2 Cytokines Predict Clinical Response in Multiple Sclerosis Patients Treated with Glatiramer Acetate.
- Authors
Tumani, Hayrettin; Kassubek, Jan; Hijazi, Mohammed; Lehmensiek, Vera; Unrath, Alexander; Süssmuth, Sigurd; Lauda, Florian; Kapfer, Tamara; Fang, Lubin; Senel, Makbule; Brettschneider, Johannes
- Abstract
The patterns of Th1/Th2 cytokines in relapsing-remitting multiple sclerosis were analyzed to evaluate their relevance as biomarkers of therapy response to glatiramer acetate (GA). Serum interferon-γ (IFN-γ), osteopontin and interleukin (IL)-2, IL-4, and IL-10 were measured in 19 relapsing-remitting multiple sclerosis patients treated with GA in a prospective study over 3 years. The quotient (IL-2 + IFN-γ)/(IL-4 + IL-10) was elevated in patients with relapses as compared to relapse-free patients after 12 (p = 0.04), 24 (p = 0.02) and 36 months (p = 0.04). Our study indicates that specific patterns of Th1/Th2 cytokines predict the response to GA therapy. Copyright © 2011 S. Karger AG, Basel
- Subjects
CYTOKINES; MULTIPLE sclerosis; BIOMARKERS; OSTEOPONTIN; INTERLEUKINS
- Publication
European Neurology, 2011, Vol 65, Issue 3, p164
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000324035