We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells.
- Authors
Sato, S; Kaneto, S; Shibata, N; Takahashi, Y; Okura, H; Yuki, Y; Kunisawa, J; Kiyono, H
- Abstract
Although many of the biological features of microfold cells (M cells) have been known for many years, the molecular mechanisms of M-cell development and antigen recognition have remained unclear. Here, we report that Umod is a novel M-cell-specific gene, the translation products of which might contribute to the uptake function of M cells. Transcription factor Spi-B was also specifically expressed in M cells among non-hematopoietic lineages. Spi-B-deficient mice showed reduced expression of most, but not all, other M-cell-specific genes and M-cell surface markers. Whereas uptake of Salmonella Typhimurium via M cells was obviously reduced in Spi-B-deficient mice, the abundance of intratissue cohabiting bacteria was comparable between wild-type and Spi-B-deficient mice. These data indicate that there is a small M-cell population with developmental regulation that is Spi-B independent; however, Spi-B is probably a candidate master regulator of M-cell functional maturation and development by another pathway.
- Subjects
PEYER'S patches; HEMATOPOIESIS; SALMONELLA typhimurium; LYMPHOID tissue; ANTIGENS; MICROVILLI
- Publication
Mucosal Immunology (1933-0219), 2013, Vol 6, Issue 4, p838
- ISSN
1933-0219
- Publication type
Article
- DOI
10.1038/mi.2012.122