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- Title
MiR‐10a‐5p restrains the aggressive phenotypes of ovarian cancer cells by inhibiting HOXA1.
- Authors
Liu, Li‐Jun; Sun, Xiao‐Yan; Yang, Chen‐Xi; Zou, Xiao‐Yan
- Abstract
MicroRNAs (miRNAs) are dysregulated in human ovarian carcinoma (OC). But the mechanism underlying miR‐10a‐5p in regulating the progression of OC need deeply explored. In the current study, we observed that miR‐10a‐5p was down‐expressed in OC samples and OC cell lines. In addition, miR‐10a‐5p restrained the viability, colony formation, migration ability and invasiveness of OC cells. We further ascertained Homeobox A1 (HOXA1) was a downstream gene of miR‐10a‐5p. Furthermore, HOXA1 was distinctly upregulated in OC samples. Finally, upregulation of HOXA1 abolished the suppressive effects of miR‐10a‐5p on OC cells. These observations suggested that miR‐10a‐5p suppressed the aggressive phenotypes of OC cells via regulating HOXA1.
- Subjects
OVARIAN cancer; CANCER cells; PHENOTYPES; GENES; CELL lines
- Publication
Kaohsiung Journal of Medical Sciences, 2021, Vol 37, Issue 4, p276
- ISSN
1607-551X
- Publication type
Article
- DOI
10.1002/kjm2.12335