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- Title
Maternal and Pup Genotype Contribution to Growth in Wild-Type and tau Mutant Syrian Hamsters.
- Authors
Oklejewicz, Malgorzata; Pen, Ido; Durieux, Geesje C.R.; Daan, Serge
- Abstract
The single gene mutation tau in the Syrian hamster—apart from its effect on the circadian organization of locomotor activity—has a pronounced influence on body weight. In this study we investigate the impact of maternal and pup genotypes at the tau -locus on the growth rate of pups. Homozygous tau mutant hamsters (circadian period of 20 hours) had lower growth rates and adult body weights than wild-type hamsters, whereas heterozygous tau mutants (circadian period of 22 hours) were intermediate. In addition, heterozygous pups from heterozygous dams grew heavier than those from wild-type and homozygous dams. The effect of maternal genotype was further evaluated in a cross-foster design, where wild-type and homozygous mutant pups were fostered at birth to either wild-type or homozygous mutant dams. At all ages, the maternal tau genotype had a negative effect on body weight, whereas the pup tau genotype had a positive effect during the preweaning period and a negative effect afterward.
- Subjects
HAMSTERS; DEVELOPMENTAL genetics; BODY weight
- Publication
Behavior Genetics, 2001, Vol 31, Issue 4, p383
- ISSN
0001-8244
- Publication type
Article
- DOI
10.1023/A:1012274419184