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- Title
Histopathological study of canine sebaceous tumors and their association with PCNA expression by immunohistochemistry*.
- Authors
Barroso Costa, Fabíola; Gomes Coelho da Silva, Kássia Valéria; da Silva Leite, Juliana; Fernandes Silva, Franciele Basso; dos Santos Batista, Bárbara Paula; de Mello e. Silva, Juliana Freitas; Reis Ferreira, Ana Maria
- Abstract
Sebaceous tumors are common in dogs. These tumors include both benign and malignant lesions. Immunohistochemical evaluation of these tumors can aggregate information regarding the origin and degree of malignancy of the lesions. Focusing on this matter, sixty-one samples including normal skin and sebaceous tumors were selected from dogs of various breeds and ages, with no predilection for sex, from the archive of Veterinary Pathology Service of Federal Fluminense University, Niterói/RJ, Brazil. The samples underwent to histological processing, routine staining and immunohistochemistry with anti-PCNA (proliferating cell nuclear antigen). Descriptive statistical analysis was performed, the Wilcoxon-Mann-Whitney test was used to compare the distribution of anti-PCNA labelling in different groups of variables. In case there were more than two groups, the Analysis of Variance (ANOVA) test was performed. The mean age of the affected animals was 10.56 years. The most affected breeds were Caniches and Cocker Spaniels, as well as mixed breed animals. There was immunostaining of PCNA in both benign and malignant tumors, as well as in hyperplasic lesions with varying intensity. Most of the tumors were neoplasms which represented 67.27% of the total sample; within these, 75.00% were benign. The most frequent neoplasm was sebaceous adenoma (37.74%). Results indicated no statistical difference in the distribution of anti-PCNA labelling between the groups of sex, age, reproductive status, localization, size of tumor, and histopathological diagnosis. Although there are not many studies analyzing anti-PCNA labelling in sebaceous tumors, several of them pointed out to the predictive value in other neoplasms. With this matter in mind, we intended to evaluate the expression of anti-PCNA in canine sebaceous tumor and a possible association with the malignancy of the lesions.
- Subjects
BRAZIL; HISTOCHEMISTRY; PROLIFERATING cell nuclear antigen; SKIN tumors; BENIGN tumors; ANIMAL breeds; VETERINARY pathology
- Publication
Brazilian Journal of Veterinary Science / Revista Brasileira de Ciência Veterinária, 2020, Vol 27, Issue 3, p150
- ISSN
1413-0130
- Publication type
Article
- DOI
10.4322/rbcv.2020.027