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- Title
O probiótico Saccharomyces boulardii modula a resposta de IgG2a em camundongos expostos aos antígenos de Leishmania infantum.
- Authors
Sousa Lima, Joelson; Presley Oliveira Sampaio, Ana Paula; da Silva, Flávio; Vasconcelos Monteiro, Maiara; Abel Bezerra, Isis; Leivas Leite, Fabio Pereira; Martins de Moraes, Carina; Bandeira Roos, Talita
- Abstract
The aim of the present study was to evaluate the effects of the Saccharomyces boulardii probiotic on the modulation of humoral immune response in animals exposed to Leishmania infantum antigens. For this, 16 BALB/c mice were immunized with Leishmania infantum particulate antigen and divided into two experimental groups, one consisting of supplemented animals and the other not probiotic supplemented animals. Blood samples from the animals were taken weekly during the experimental period and subjected to the Indirect Enzyme-Linked Immunosorbance Assay for evaluation of total IgG titers and the profile of the produced IgG isotypes (IgG1 and IgG2a). Probiotic supplementation did not exacerbate total IgG production compared to the control group, with no significant differences between the two groups. However, IgG2a seroconversions were higher in the supplemented group, which showed a 1.46-fold increase at the end of the experiment. Thus, supplementation with S. boulardii was able to modulate the IgG2a/IgG1 response in animals exposed to Leishmania infantum antigens.
- Subjects
HUMORAL immunity; PROBIOTICS; LEISHMANIA infantum; PRODUCTION control; SACCHAROMYCES; IMMUNOREGULATION; EXPERIMENTAL groups
- Publication
Brazilian Journal of Veterinary Science / Revista Brasileira de Ciência Veterinária, 2019, Vol 26, Issue 4, p137
- ISSN
1413-0130
- Publication type
Article
- DOI
10.4322/rbcv.2019.024