We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Exposure‐Response Modeling Analyses for Sirukumab, a Human Monoclonal Antibody Targeting Interleukin 6, in Patients With Moderately to Severely Active Rheumatoid Arthritis.
- Authors
Xu, Yan; Hu, Chuanpu; Zhuang, Yanli; Hsu, Benjamin; Xu, Zhenhua; Sharma, Amarnath; Zhou, Honghui
- Abstract
Abstract: To characterize the dose‐exposure–response relationship of sirukumab, an anti–interleukin 6 human monoclonal antibody, in the treatment of moderately to severely active rheumatoid arthritis (RA), we conducted exposure‐response (E‐R) modeling analyses based on data from two pivotal phase 3 placebo‐controlled trials of sirukumab in patients with RA who were inadequate responders to nonbiologic disease‐modifying antirheumatic drugs or anti‐tumor necrosis factor α agents. A total of 2176 patients were included for the analyses and received subcutaneous administration of either placebo or sirukumab 50 mg every 4 weeks or 100 mg every 2 weeks. The clinical endpoints were 20%, 50%, and 70% improvement in the American College of Rheumatology response criteria (ie, ACR20, ACR50, and ACR70), and 28‐joint Disease Activity Index Score (DAS28) using C‐reactive protein. To provide a thorough assessment of the sirukumab E‐R relationship, 2 pharmacokinetic/pharmacodynamic modeling approaches were implemented, including joint longitudinal modeling (ie, indirect response modeling of the time course of the 2 clinical endpoints) and landmark analyses (ie, direct linking of selected pharmacokinetic parameters to response at week 16 or 24). Results from both modeling analyses were generally consistent, and collectively suggested that the sirukumab subcutaneous dose of 50 mg every 4 weeks would produce near‐maximal efficacy. No covariates identified in the E‐R modeling analyses would have a significant impact on dose‐response. Despite body weight and comorbid diabetes having significant effect on sirukumab exposure, simulations suggested that their effect on efficacy was small. Our work provides a comprehensive evaluation of sirukumab E‐R to support dose recommendations in patients with RA.
- Subjects
AMERICA; THERAPEUTIC use of monoclonal antibodies; SUBCUTANEOUS injections; BODY weight; C-reactive protein; DIABETES; DOSE-effect relationship in pharmacology; INTERLEUKINS; JOINTS (Anatomy); LONGITUDINAL method; MONOCLONAL antibodies; RHEUMATOID arthritis; TUMOR necrosis factors; COMORBIDITY; RANDOMIZED controlled trials; TREATMENT effectiveness; SEVERITY of illness index
- Publication
Journal of Clinical Pharmacology, 2018, Vol 58, Issue 11, p1501
- ISSN
0091-2700
- Publication type
Article
- DOI
10.1002/jcph.1272