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- Title
Anti-avian influenza virus H<sub>9</sub>N<sub>2</sub> activity of aqueous extracts of Zingiber officinalis (Ginger) and Allium sativum (Garlic) in chick embryos.
- Authors
Rasool, Amir; Khan, Muti-ur-Rehman; Asad Ali, Muhammad; Anjum, Aftab Ahmad; Ahmed, Ishtiaq; Aslam, Asim; Mustafa, Ghulam; Masood, Saima; Ali, Muhammad Amjad; Nawaz, Muhammad
- Abstract
In the present study, anti-Avian influenza virus H9N2 activity of aqueous extracts (5, 10, 15, 20, 25%) of Zingiber officinalis and Allium sativum was evaluated. Embryo-toxicity was evaluated by histopathological scoring of Chorio-allantoic membrane of chick embryos. Cytotoxicity of extracts was determined by MTT assay on Vero cells. Aqueous extract of ginger had antiviral activity at 10, 15, 20 and 25% while garlic had activity at 15, 20 and 25%. Histopathological scoring of chorio-allantoic membrane for aqueous extracts (5, 10, 15, 20, 25%) of ginger (0.66±0.57, 1.33±0.57, 1.66±0.57, 2.66±0.57, 3.66±0.57, respectively) and garlic (1.00±0.00, 1.33±0.57, 2.00±0.00, 2.33±0.57, 3.66±0.57, respectively) was concentration dependant. MTT assay revealed cytotoxicity of both plants was also concentration dependent. Extracts of ginger (5, 10, 15, 20, 25%) had lower cytotoxicity (71, 59, 28, 22, 0 % cell survival, respectively) as compared to garlic (61, 36. 20, 11, 3% cell survival, respectively). Overall results revealed that concentration of aqueous extract of ginger (10%), showing antiviral activity against H9N2, was less toxic to vero cells (> 50% cell survival). It is insinuated that ginger may have anti- Avian influenza virus H9N2 potential and its active compounds needs further investigation
- Subjects
INFLUENZA transmission; INFLUENZA treatment; ANTIVIRAL agents; ANTINEOPLASTIC agents; CHICKEN embryos; RESPIRATORY infections; DISEASE risk factors
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2017, Vol 30, Issue 4, p1341
- ISSN
1011-601X
- Publication type
Article