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- Title
Asetil salisilik asit'in radyokoruyucu etkisi.
- Authors
DEMİREL, Can; KILÇIKSIZ, Sevil
- Abstract
Ionizing radiation cell injury occurs by means of oxidative/nitrosative stress mediators. Protection of normal tissues from damage might increase the therapeutic ratio. It is shown that acetylsalicylic acid (ASA), a member of the non-steroidal antiinflammatory group, can inhibit the release of prostaglandins that play a role in many forms of tissue damages and might prevent tissue/cell damages in various diseases with its similar anti-oxidant properties. With clinical/preclinical studies, it is demonstrated that ASA can reduce oxidative damage/injury and that it has a place in protection from cancer. It might be stated that it reduces radiation/irradiation-based geno-cytotoxicity. ASA is an agent that has not yet been used as a radioprotector in the clinic, and it is worth being supported with more advanced studies. In this examination, it is intended to discuss the current role of ASA as a radioprotector.
- Subjects
ASPIRIN; IONIZING radiation; PROSTAGLANDINS; OXIDATIVE stress; CELL-mediated cytotoxicity
- Publication
Turkish Journal of Oncology / Türk Onkoloji Dergisi, 2011, Vol 26, Issue 1, p45
- ISSN
1300-7467
- Publication type
Article
- DOI
10.5505/tjoncol.2011.546