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- Title
Diagnostic efficacy of contrast-enhanced breast MRI versus X-ray mammography in women with different degrees of breast density.
- Authors
Barkhausen, Jörg; Bischof, Arpad; Haverstock, Daniel; Klemens, Mark; Brueggenwerth, Guenther; Weber, Olaf; Endrikat, Jan
- Abstract
<bold>Background: </bold>Detection of breast cancer in women with high breast densities is a clinical challenge.<bold>Purpose: </bold>To study the influence of different degrees of breast density on the sensitivity of contrast-enhanced breast magnetic resonance imaging (CE-BMRI) versus X-ray mammography (XRM).<bold>Material and Methods: </bold>We performed an additional analysis of two large Phase III clinical trials (G1; G2) which included women with histologically proven breast cancers, called "index cancers." Additional cancers were detected during image reading. We compared the sensitivity of CE-BMRI and XRM in women with different breast densities (ACR A→D; Version 5). For each study, six blinded readers evaluated the images. Results are given as the "Median Reader."<bold>Results: </bold>A total of 774 patients were included, 169 had additional cancers. While sensitivity of CE-BMRI for detecting all index cancers was independent of breast density (ACR A→D) (G1: 83%→83%; G2: 91%→91%) the sensitivity of XRM declined (ACR A→D) (G1: 79%→62%; G2: 82%→64%). Thus, the sensitivity difference between both imaging modalities in ACR A breasts of 3% (G1) and 9% (G2) increased to 21% (G1) and 26% (G2) in ACR D breasts. Sensitivity of CE-BMRI for detecting at least one additional cancer increased with increasing breast density (ACR A→D) (G1: 50%→73%, G2: 57%→81%). XRM's sensitivity decreased (G1: 34%→20%) or remained stable (G2: 24%→25%).<bold>Conclusion: </bold>CE-BMRI showed significantly higher sensitivity compared to XRM.
- Subjects
MAGNETIC resonance mammography; CONTRAST-enhanced magnetic resonance imaging; MAMMOGRAMS; X-rays; BREAST cancer; MAGNETIC resonance imaging; CONTRAST media; COMPARATIVE studies; BREAST tumors
- Publication
Acta Radiologica, 2021, Vol 62, Issue 5, p586
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.1177/0284185120936271