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- Title
Serum High-Sensitivity C-Reactive Protein and Heat Shock Protein 27 Antibody Titers in Patients With Stroke and 6-Month Prognosis.
- Authors
Azarpazhooh, Mahmoud Reza; Mobarra, Naser; Parizadeh, Syyed Mohammad Reza; Tavallaie, Shima; Bagheri, Mahsa; Rahsepar, Amir Ali; Ghayour-Mobarhan, Majid; Sahebkar, Amirhossein; Ferns, Gordon A. A.
- Abstract
Serum heat shock protein 27 immunoglobulin G (IgG) antibody titers (anti-HSP27) and high-sensitivity C-reactive protein (hsCRP) concentrations were measured in samples from 168 patients in the first 24 hours after the onset of stroke and 80 age- and sex-matched control participants. In patients with stroke, median serum anti-HSP27 titer was significantly higher than that of the control group (0.18 [0.14-0.28] vs 0.08 [0.04-0.12], P < .001). Median serum hsCRP concentration was also significantly higher in patients compared with the control group (11.43 [8.07-13.53] vs 3.23 [1.66-6.24], P < .001). Serum anti-HSP27 and hsCRP concentrations did not differ significantly among patients with different stroke types. Neither serum anti-HSP27 nor hsCRP levels predicted 6-month prognosis in the patients with stroke. We conclude that serum anti-HSP27 titers and hsCRP concentrations are elevated in patients with stroke but do not distinguish between stroke types or predict 6-month prognosis.
- Subjects
CEREBROVASCULAR disease patients; C-reactive protein; HEAT shock proteins; PROGNOSIS; ANTIBODY titer; SEROLOGY; BLOOD testing
- Publication
Angiology, 2010, Vol 61, Issue 6, p607
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319709360524