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- Title
Controlled Studies of Daflon 500 mg in Chronic Venous Insufficiency.
- Authors
Geroulakos, George; Nicolaides, Andrew N.
- Abstract
Although great advances have been made in the operative treatment of vascular disorders, the management of most venous problems is still nonsurgical, Daflon 500 mg is a micronized flavonoid mixture of 90% diosmin and 10% hesperidin that has phlebotonic properties. The efficacy of Daflon 500 mg has been investigated in three double-blind, randomized trials using strain gauge plethysmography to provide quantitative information on venous hemodynamics in patients with chronic venous insufficiency. In total, 183 patients were treated with Daflon 500 mg versus a control group of equal number of patients, Daflon 500 mg produced a significant decrease in venous capacitance, venous distensibility, and venous emptying time (PΛ0,001), In addition, these changes were accompanied by improvement in clinical symptoms and a decrease in the supramalleolar circumference. Clinical side effects were rare and led to treatment withdrawal in only 3 patients. It is concluded that Daflon 500 mg is of benefit to patients with chronic venous insufficiency.
- Subjects
DRUG efficacy; VASCULAR diseases; THERAPEUTICS; VENOUS insufficiency; PLETHYSMOGRAPHY; HEMODYNAMICS
- Publication
Angiology, 1994, Vol 45, p549
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/000331979404500609