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- Title
Diverse functions and pathogenetic role of Crumbs in retinopathy.
- Authors
Zhou, Xuebin; Zhao, Liangliang; Wang, Chenguang; Sun, Wei; Jia, Bo; Li, Dan; Fu, Jinling
- Abstract
The Crumbs protein (CRB) family plays a crucial role in maintaining the apical–basal polarity and integrity of embryonic epithelia. The family comprises different isoforms in different animals and possesses diverse structural, localization, and functional characteristics. Mutations in the human CRB1 or CRB2 gene may lead to a broad spectrum of retinal dystrophies. Various CRB-associated experimental models have recently provided mechanistic insights into human CRB-associated retinopathies. The knowledge obtained from these models corroborates the importance of CRB in retinal development and maintenance. Therefore, complete elucidation of these models can provide excellent therapeutic prospects for human CRB-associated retinopathies. In this review, we summarize the current animal models and human-derived models of different CRB family members and describe the main characteristics of their retinal phenotypes.
- Subjects
RETINAL degeneration; ADHERENS junctions; ANIMAL models in research; PHENOTYPES; CELL polarity
- Publication
Cell Communication & Signaling, 2024, Vol 22, Issue 1, p1
- ISSN
1478-811X
- Publication type
Article
- DOI
10.1186/s12964-024-01673-z