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- Title
A randomized controlled trial to evaluate the effectiveness of a novel mouth rinse in patients with gingivitis.
- Authors
Newman, Bianca A.; Rosebrough, Claire N.; Tamashiro, Ryan A.; Dias Ribeiro, Ana P.; Whitlock, Joan A.; Sidhu, Gurjit; Aukhil, Ikramuddin; Porral, Dianne Y.; Progulske-Fox, Ann; Myntti, Matthew F.; Wang, Gary P.
- Abstract
Background: This single-center, randomized controlled trial aimed to determine the effectiveness of a novel, biofilm-disrupting, mouth rinse that combines Cetylpyridinium chloride (CPC) and essential oils in preventing re-accumulation of supragingival plaque and supragingival microbiome in patients with gingivitis after dental prophylaxis. Methods: One hundred eighteen participants were randomly assigned in a 1:1 ratio to receive twice-daily test mouth rinse (59) or carrier rinse control (59) for 12 weeks after dental prophylaxis. Results: In a per-protocol analysis that included patients who completed the intervention, the treatment group (39) had significantly lower supragingival plaque scores at 6 and 12 weeks compared to the control group (41; p = 0.022). Both groups showed similar improvement in gingivitis score, but neither group had improvement in bleeding score or probing depth. Thirty-eight (29%) patients did not complete the study due to loss of follow-up (17) or early discontinuation of the assigned intervention (21). Microbiome sequencing showed that the treatment rinse significantly depleted abundant and prevalent members of the supragingival plaque microbiome consortium. Conclusions: Among patients with gingivitis, the novel mouth rinse significantly reduced re-accumulation of supragingival plaque following dental prophylaxis by depleting supragingival plaque microbiome. However, long-term adherence to the rinse may be limited by adverse effects (ClinicalTrials.gov number, NCT03154021).
- Subjects
FLORIDA; THERAPEUTIC use of essential oils; DISEASE relapse prevention; PYRIDINE; DRUG efficacy; STATISTICS; GINGIVITIS; DENTAL plaque; SEQUENCE analysis; ANALYSIS of variance; MOUTHWASHES; MULTIVARIATE analysis; BIOFILMS; MANN Whitney U Test; DENTAL prophylaxis; RANDOMIZED controlled trials; BIOINFORMATICS; HUMAN microbiota; DESCRIPTIVE statistics; STATISTICAL sampling; STATISTICAL models; DATA analysis; LONGITUDINAL method
- Publication
BMC Oral Health, 2022, Vol 22, Issue 1, p1
- ISSN
1472-6831
- Publication type
Article
- DOI
10.1186/s12903-022-02518-2