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- Title
Dissemination of clonal complex 2 Acinetobacter baumannii strains co-producing carbapenemases and 16S rRNA methylase ArmA in Vietnam.
- Authors
Tatsuya Tada; Tohru Miyoshi-Akiyama; Kayo Shimada; Tran Thi Thanh Nga; Le Thi Anh Thu; Nguyen Truong Son; Norio Ohmagari; Teruo Kirikae; Tada, Tatsuya; Miyoshi-Akiyama, Tohru; Shimada, Kayo; Nga, Tran Thi Thanh; Thu, Le Thi Anh; Son, Nguyen Truong; Ohmagari, Norio; Kirikae, Teruo
- Abstract
<bold>Background: </bold>Acinetobacter baumannii strains co-producing carbapenemase and 16S rRNA methylase are highly resistant to carbapenems and aminoglycosides. <bold>Methods: </bold>Ninety-three isolates of multidrug-resistant A. baumannii were obtained from an intensive care unit in a hospital in Vietnam. Antimicrobial susceptibility tests and whole genome sequencing were performed. Multilocus sequence typing and the presence of drug resistant genes were determined and a maximum-likelihood phylogenetic tree was constructed by SNP alignment of whole genome sequencing data. <bold>Results: </bold>The majority of isolates belonged to clonal complex 2 (ST2, ST570 and ST571), and carried carbapenemase encoding genes bla OXA-23 and bla OXA-66. Two isolates encoded carbapenemase genes bla NDM-1 and bla OXA-58 and the 16S rRNA methylase encoding gene armA and did not belong to clonal complex 2 (ST16). <bold>Conclusion: </bold>A. baumannii isolates producing 16S rRNA methylase ArmA and belonging to clonal complex 2 are widespread, and isolates co-producing NDM-1 and ArmA are emerging, in medical settings in Vietnam.
- Subjects
VIETNAM; BACTERIAL protein metabolism; DRUG resistance in microorganisms; GENETIC polymorphisms; GENOMES; HYDROLASES; INTENSIVE care units; MICROBIAL sensitivity tests; RNA; TRANSFERASES; GRAM-negative aerobic bacteria; SEQUENCE analysis
- Publication
BMC Infectious Diseases, 2015, Vol 15, p433
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-015-1171-x