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- Title
Calcium in atrial fibrillation -- pulling the trigger or not?
- Authors
Gomez-Hurtado, Nieves; Knollmann, Björn C.
- Abstract
Atrial fibrillation (AF) is the most common sustained arrhythmia disease. Current drug- and surgical-based therapies are ineffective in about 40% to 50% of AF patients; therefore, there is a great need to better understand the underlying mechanisms of this disease and identify potential therapeutic targets. In this issue of the JCI, Greiser and coworkers discovered that atrial remodeling in response to sustained tachycardia silences Ca2+ signaling in isolated rabbit and human atrial myocytes. This Ca2+ release silencing was attributable to a failure of subcellular propagated Ca2+ release due to an increased cytosolic buffering strength. The results from this study challenge the current paradigm that Ca2+ release instability underlies AF. Instead, Ca2+ silencing could be protective against the massive cellular Ca2+ loading that occurs during chronic AF.
- Subjects
ATRIAL fibrillation treatment; TREATMENT effectiveness; TACHYCARDIA treatment; LABORATORY rabbits; MUSCLE cells
- Publication
Journal of Clinical Investigation, 2014, Vol 124, Issue 11, p4684
- ISSN
0021-9738
- Publication type
Article
- DOI
10.1172/JCI77986