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- Title
Delta Variant of SARS-CoV-2 Replacement in Brazil: A National Epidemiologic Surveillance Program.
- Authors
Silva, Joice P.; de Lima, Aline B.; Alvim, Luige B.; Malta, Frederico S. V.; Mendonça, Cristiane P. T. B.; Fonseca, Paula L. C.; Moreira, Filipe R. R.; Queiroz, Daniel C.; Ferreira, Jorge G. G.; Ferreira, Alessandro C. S.; Souza, Renan P.; Aguiar, Renato S.; Zauli, Danielle A. G.
- Abstract
Coronavirus disease 2019 (COVID-19) pandemic has caused immeasurable impacts on the health and socioeconomic system. The real-time identification and characterization of new Variants of Concern (VOCs) are critical to comprehend its emergence and spread worldwide. In this sense, we carried out a national epidemiological surveillance program in Brazil from April to October 2021. Genotyping by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and sequencing were performed to monitor the dynamics and dissemination of VOCs in samples from 15 federative units. Delta VOC was first detected on June 2021 and took sixteen weeks to replace Gamma. To assess the transmissibility potential of Gamma and Delta VOCs, we studied the dynamics of RT-qPCR cycle threshold (Ct) score in the dominance period of each variant. The data suggest that Delta VOC has a higher transmission rate than Gamma VOC. We also compared relevant symptom patterns in individuals infected with both VOCs. The Delta-infected subjects were less likely to have low oxygen saturation or fatigue, altered results on chest computed tomography, and a propensity for altered X-rays. Altogether, we described the replacement of Gamma by Delta, Delta enhanced transmissibility, and differences in symptom presentation.
- Subjects
BRAZIL; COVID-19; SARS-CoV-2 Delta variant; POLYMERASE chain reaction; OXYGEN saturation
- Publication
Viruses (1999-4915), 2022, Vol 14, Issue 5, p847
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v14050847