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- Title
Frontispiece: Chemical Synthesis of Bioactive Naturally Derived Cyclic Peptides Containing Ene‐Like Rigidifying Motifs.
- Authors
De Leon Rodriguez, Luis M.; Williams, Elyse T.; Brimble, Margaret A.
- Abstract
There has been a growing interest to develop chemical approaches for the synthesis of highly constrained, naturally derived cyclopeptides. It is known that structural rigidity correlates with the specificity, bioactivity, and stability of these peptide systems, thus rigid systems are particularly attractive leads for development of potent biopharmaceuticals. Recent advances have provided excellent new strategies to overcome the challenges involved, broadening the repertoire of available methodology. For more information, see the Minireview by M. A. Brimble et al. on page 17869 ff.
- Subjects
CHEMICAL synthesis; CYCLIC peptides; ORGANIC cyclic compounds; PEPTIDES; BIOPHARMACEUTICS
- Publication
Chemistry - A European Journal, 2018, Vol 24, Issue 68, pN.PAG
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201886862