We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Conflict in the Intracellular Lives of Endosymbionts and Viruses: A Mechanistic Look at Wolbachia-Mediated Pathogen-blocking.
- Authors
Lindsey, Amelia R. I.; Bhattacharya, Tamanash; Newton, Irene L. G.; Hardy, Richard W.
- Abstract
At the forefront of vector control efforts are strategies that leverage host-microbe associations to reduce vectorial capacity. The most promising of these efforts employs <italic>Wolbachia</italic>, a maternally transmitted endosymbiotic bacterium naturally found in 40% of insects. <italic>Wolbachia</italic> can spread through a population of insects while simultaneously inhibiting the replication of viruses within its host. Despite successes in using <italic>Wolbachia</italic>-transfected mosquitoes to limit dengue, Zika, and chikungunya transmission, the mechanisms behind pathogen-blocking have not been fully characterized. Firstly, we discuss how <italic>Wolbachia</italic> and viruses both require specific host-derived structures, compounds, and processes to initiate and maintain infection. There is significant overlap in these requirements, and infection with either microbe often manifests as cellular stress, which may be a key component of <italic>Wolbachia</italic>’s anti-viral effect. Secondly, we discuss the current understanding of pathogen-blocking through this lens of cellular stress and develop a comprehensive view of how the lives of <italic>Wolbachia</italic> and viruses are fundamentally in conflict with each other. A thorough understanding of the genetic and cellular determinants of pathogen-blocking will significantly enhance the ability of vector control programs to deploy and maintain effective <italic>Wolbachia</italic>-mediated control measures.
- Subjects
DENGUE; WOLBACHIA; RICKETTSIACEAE; PATHOGENIC microorganisms; CHIKUNGUNYA; INFECTIOUS disease transmission
- Publication
Viruses (1999-4915), 2018, Vol 10, Issue 4, p141
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v10040141