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- Title
Extracellular Matrix Remodelling: Obesity‐Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling (Adv. Funct. Mater. 48/2020).
- Authors
Ling, Lu; Mulligan, Jeffrey A.; Ouyang, Yunxin; Shimpi, Adrian A.; Williams, Rebecca M.; Beeghly, Garrett F.; Hopkins, Benjamin D.; Spector, Jason A.; Adie, Steven G.; Fischbach, Claudia
- Abstract
Extracellular Matrix Remodelling: Obesity-Associated Adipose Stromal Cells Promote Breast Cancer Invasion through Direct Cell Contact and ECM Remodeling (Adv. Funct. Keywords: collagen; extracellular matrix remodeling; obesity; optical coherence tomography; tumor invasion EN collagen extracellular matrix remodeling obesity optical coherence tomography tumor invasion 1 1 1 11/27/20 20201125 NES 201125 In article number 1910650, Claudia Fischbach and co-workers combine collagen-embedded multicellular spheroids and advanced imaging to investigate the effect of adipose stromal cells (ASCs) on tumor cell invasion as a function of obesity. Obese ASCs increase collective tumor cell migration relative to lean ASCs by stimulating proteolytic and contractility-dependent collagen remode ling, providing insights into how obesity promotes breast cancer malignancy.
- Subjects
FAT cells; EXTRACELLULAR matrix; STROMAL cells; BREAST cancer; OPTICAL coherence tomography
- Publication
Advanced Functional Materials, 2020, Vol 30, Issue 48, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202070320