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- Title
Forearm Bone Mineral Density Varies as a Function of Adiposity in Inuit Women 40-90 Years of Age During the Vitamin D-Synthesizing Period.
- Authors
El Hayek, Jessy; Pronovost, Amy; Morin, Suzanne; Egeland, Grace; Weiler, Hope
- Abstract
Aging Inuit women are at increased risk for low vitamin D status due to habitation at higher latitudes, darker skin, and ongoing nutrition transition. Lower serum 25-hydroxyvitamin D (25[OH]D) concentration and higher risk of fracture have been separately reported in Inuit women, with particular relevance to postmenopausal women. We evaluated vitamin D status, forearm bone mineral density (fBMD), and nutrition in Inuit women ≥40 years. Women ( n = 568) were randomly selected to participate in the 2007-2008 International Polar Year Inuit Health Survey from 36 Arctic communities. fBMD was measured using peripheral dual-energy X-ray absorptiometry. Dietary intakes were derived from 24 h recall and food-frequency questionnaires. Fasting serum 25(OH)D, parathyroid hormone, and osteocalcin (OC) were measured using a LIAISON automated analyzer. The weighted prevalence of women having 25(OH)D concentration below 37.5, 50, and 75 nmol/L was 7.2 %, 17.6 %, and 48.6 %, respectively, with older women having better status. The dietary density of most nutrients increased with age, as did traditional food intake. fBMD was low in 3 (1.4 %) premenopausal (Z score < −2) and 107 (29.6 %) postmenopausal (T score < −1.5) women. Regression revealed that either weight, body mass index, or percent body fat significantly predicted fBMD in premenopausal women, in addition to age and OC in postmenopausal women. Women ≥50 years have higher vitamin D status and more nutrient-dense diets than women 40-49 years. While measures of adiposity predicted fBMD in all women, additional predictors after menopause included age and bone turnover.
- Subjects
BONE density; FOREARM; OBESITY; INUIT women; VITAMIN D; RISK factors of fractures; DUAL-energy X-ray absorptiometry
- Publication
Calcified Tissue International, 2012, Vol 90, Issue 5, p384
- ISSN
0171-967X
- Publication type
Article
- DOI
10.1007/s00223-012-9583-8