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- Title
Discovering the strength of immunometabolism in cancer therapy: Employing metabolic pathways to enhance immune responses.
- Authors
Huldani, Huldani; Malviya, Jitendra; Rodrigues, Paul; Hjazi, Ahmed; Deorari, Maha Medha; Al‐Hetty, Hussein Riyadh Abdul Kareem; Qasim, Qutaiba A.; Alasheqi, Mohammed Qasim; Ihsan, Ali
- Abstract
Immunometabolism, which studies cellular metabolism and immune cell function, is a possible cancer treatment. Metabolic pathways regulate immune cell activation, differentiation, and effector functions, crucial to tumor identification and elimination. Immune evasion and tumor growth can result from tumor microenvironment metabolic dysregulation. These metabolic pathways can boost antitumor immunity. This overview discusses immune cell metabolism, including glycolysis, oxidative phosphorylation, amino acid, and lipid metabolism. Amino acid and lipid metabolic manipulations may improve immune cell activity and antitumor immunity. Combination therapy using immunometabolism‐based strategies may enhance therapeutic efficacy. The complexity of the metabolic network, biomarker development, challenges, and future approaches are all covered, along with a summary of case studies demonstrating the effectiveness of immunometabolism‐based therapy. Metabolomics, stable isotope tracing, single‐cell analysis, and computational modeling are also reviewed for immunometabolism research. Personalized and combination treatments are considered. This review adds to immunometabolism expertise and sheds light on metabolic treatments' ability to boost cancer treatment immunological response. Also, in this review, we discussed the immune response in cancer treatment and altering metabolic pathways to increase the immune response against malignancies. Significance statement: Optimizing immunometabolism‐based approaches as potential cancer therapy.The potential of metabolic pathways altering to boost the immune response against malignancies.Effects of targeting metabolic pathways on immune cell activity and antitumor responses.Determining the metabolic network complexity as difficulties and future directions.
- Subjects
IMMUNE response; CANCER treatment; CELL metabolism; LIPID metabolism; OXIDATIVE phosphorylation
- Publication
Cell Biochemistry & Function, 2024, Vol 42, Issue 2, p1
- ISSN
0263-6484
- Publication type
Article
- DOI
10.1002/cbf.3934